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Cat. No. Product Name Target Signaling Pathways
T7752 (S,R,S)-AHPC-Me

VHL ligand 2,E3 ligase Ligand 1A

Ligand for E3 Ligase PROTAC
(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) 是基于 (S,R,S)-AHPC 的的 VHL 配体,可用于募集 von Hippel-Lindau (VHL) 蛋白。它可有效降解去势抵抗性前列腺癌细胞中的 BET 蛋白,DC50<1 nM。它可用于合成 ARV-771。
T13671 (S,R,S)-AHPC-Me hydrochloride

VHL ligand 2 hydrochloride,E3 ligase Ligand 1

Others; Ligand for E3 Ligase Others; PROTAC
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cells resistant to castration, exhibiting a remarkable DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, (S,R,S)-AHPC-Me hydrochloride serves as the VHL ligand derived from (S,R,S)-AHPC for the recruitment of von Hippel-Lindau (VHL) protein.
T13671L (S,R,S)-AHPC-Me dihydrochloride

VHL ligand 2 dihydrochloride,E3 ligase Ligand 1 dihydrochloride,(S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)

Others Others
(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound utilized in the synthesis of ARV-771. ARV-771, a BET PROTAC degrader relying on von Hippel-Landau (VHL) E3 ligase, demonstrates potent degradation of BET protein in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound serves as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, that facilitates the recruitment of von Hippel-Lindau (VHL) prote...

化合物

(S,R,S)-AHPC-Me
Cat.No: T7752
Synonym: VHL ligand 2,E3 ligase Ligand 1A
Target: Ligand for E3 Ligase
(S,R,S)-AHPC-Me hydrochloride
Cat.No: T13671
Synonym: VHL ligand 2 hydrochloride,E3 ligase Ligand 1
Target: Others, Ligand for E3 Ligase
(S,R,S)-AHPC-Me dihydrochloride
Cat.No: T13671L
Synonym: VHL ligand 2 dihydrochloride,E3 ligase Ligand 1 dihydrochloride,(S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)
Target: Others
TargetMol Loading
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